Tottenham have been left reeling from a 4-2 defeat against north London rivals Arsenal at the weekend, but it would be a real sucker punch if they lost to Southampton in their next game.
Spurs are now fifth in the Premier League table after their result at the Emirates Stadium and just a point separates them to third-placed Chelsea.
Mauricio Pochettino’s side will be keen to bounce back immediately and get the chance at Wembley against Southampton on Wednesday night in the league.
Spurs will be strong favourites against a Southampton team in the relegation places and with just one victory all season, which has seen Mark Hughes sacked as the club’s manager prior to the game.
But the Saints still pose a threat after earning a draw with Manchester United in their last match and have a couple of dangerous players.
Midfielder Stuart Armstrong has been a revelation in recent weeks for Southampton and is beginning to show the kind of form he regularly turned in for ex-club Celtic.
The 26-year-old Scotsman has scored three times in his last two games and has a knack of arriving late into the box.
Spurs need to ensure they limit the playmaker’s influence given his form and that could be a task for defensive midfielder Eric Dier.
There are rarely any easy fixtures in the league and the pressure is on Pochettino’s side to get back to winning ways.