Tottenham have reportedly been dealt the hammer blow that defender Jan Vertonghen may be out of action until November.
According to Belgian publication HLN, the 31-year-old centre-back is not due to return to action from a hamstring injury until next month.
The Belgium international is a vital part of the Spurs backline and his absence for upcoming fixtures would be a major setback.
The North London club host Cardiff City at the weekend in the Premier League, before a trip to West Ham after the international break.
Mauricio Pochettino’s side then face PSV Eindhoven away in the Champions League group stages and also have a home clash with Manchester City in the league before the end of September.
Vertonghen’s absence for such key fixtures will be a concern for Spurs, as he’s been a key member at the heart of the defence in recent years.
It could be left to Toby Alderweireld and Davinson Sanchez to make up the centre-back pairing, as Spurs try to keep the pace with the leaders of the Premier League.
Meanwhile, they have lost their opening two Champions League matches and face a tough battle to progress from their group.