Both sides have started the new season well, with Liverpool sitting top of the pile with four wins from their opening four games.
Spurs slipped up against Watford before the international break and will be hoping to bounce back against Jurgen Klopp’s side.
Many talented players will take to the field at Wembley Stadium, but who makes into a theoretical combined XI?
Goalkeeper – Alisson (Liverpool)
Despite his howler against Leicester City, Alisson gets the nod over Hugo Lloris.
The Frenchman may have won the World Cup, but he appears to make slightly more errors than the Brazilian.
There really is little between the two, but Alisson’s shot-stopping and distribution give a slight edge.
Right back – Kieran Trippier (Tottenham)
Trippier is probably second only to Kyle Walker in the Premier League’s best right backs department – even that is arguable.
Trent Alexander-Arnold is looking very promising, but Trippier is a quality full back, who has good attacking attributes as well as defensive ones. His delivery is second to none.
Centre back – Toby Alderweireld
Possibly the best in the league. Alderweireld has everything a modern day centre-half should have; aggression, speed, positioning and distribution.
He excels in all areas of defending and is a nightmare opponent for even the Sergio Agueros and Pierre-Emerick Aubameyangs of the world.
Centre back – Virgil van Dijk
If Alderweireld isn’t the best then van Dijk probably is. The Dutchman has totally transformed Liverpool’s backline and is the commanding leader the Reds have been missing since Jamie Carragher.
An honourable mention to Jan Vertonghen.
Left back – Andy Robertson
Robertson makes it into this team because he does everything well.
The new Scotland captain’s work rate is outstanding and his attacking output is a genuine weapon for Liverpool.
What’s more, it’s difficult to pinpoint any glaring defensive mistakes he’s made since joining from Hull City last year.
Defensive midfield – Mousa Dembele
There are a few candidates for this role, but none better suited than Tottenham’s Mousa Dembele.
He may not be at the peak of his powers any more, but the Belgian still shows he can be a powerhouse ball carrier from deep.
Dembele is so strong and technical; he really does offer what many others cannot.
Attacking midfield – Christian Eriksen
Eriksen has started the 2018/19 campaign a little lethargically, but he’s still a top-class player.
His playmaking abilities are, at times, up there with the very best in Europe.
The Dane makes things happen and has been one of Tottenham’s most underrated players over the past few years.
Attacking midfield – Naby Keita
Keita looks like he’s going to take the Premier League by storm this year.
The summer signing from RB Leipzig is one of those rare all-round central midfielders who is literally good at everything.
Probably the best aspect of his game though is how quickly he can burst from defence to attack. He is impressively comfortable dribbling at speed or playing precision through balls.
Right wing – Mo Salah
Last year’s Player of the Season was never not making it in.
Mo Salah is arguably the most dangerous players in the Premier League and is a total nightmare for defenders to try and keep tabs on.
Salah is brilliant at finding pockets of space and, as evidenced last season, his finishing has improved unbelievably.
Left wing – Sadio Mane
Mane has started the 2018/19 campaign very much in the same way as Salah did last year.
The Senegalese speed demon is knocking on the door of world class these days, and he may come in for more appreciation this term with Salah unlikely to replicate his form from 2017/18.
Just like Salah, Mane is brilliantly unpredictable and a full back’s nightmare.
Striker – Harry Kane
Roberto Firmino is unlucky to miss out, but Kane cannot be overlooked.
The Englishman is one of the very best number nines in world football, and perhaps only Cristiano Ronaldo and Robert Lewandowski would get the nod over him in a combined XI.
Kane is just a lethal goalscorer, which surely is of the utmost importance for any striker.