HLN has reported Spurs have accepted defeat in trying to convince the Belgian of signing a new deal after failing to agree on wages.
Therefore, Tottenham will sell the 29-year-old this summer, with £43 million the asking price.
Tottenham could be looking for a new signing in the summer to replace him, but rather than spending big on a new recruit, they should instead give a chance to someone already at the club.
The player in question is Argentine defender Juan Foyth.
Spurs brought in the young defender from Estudiantes last summer for a fee reported to be in the region of £10 million by ESPN.
His signature was heralded as a success for the London outfit after the Times had reported PSG had instead got the youngster.
Foyth has played just eight times for Tottenham this season, with none of those appearances coming in the Premier League.
But at just 20-years-old and new to English football, that was to be expected.
Mauricio Pochettino is known to be a huge fan of his countryman and Foyth has impressed in the FA Cup this season.
As a ball playing centre-half he is the type of player Tottenham want at the back to take the team into the future.
With Alderweireld gone, Tottenham will be short a defensive option.
Jan Vertonghen will be the pillar in the centre of defence, with Davinson Sanchez an impressive talent alongside him.
Eric Dier’s versatility makes him an option. Foyth would then argue the case that he is next in line and deserves a shot at establishing himself in the Tottenham first-team.
It is certainly a possibility.
Tottenham also have highly-rated American defender Cameron Carter-Vickers out on loan at Ipswich Town, who could take Foyth’s place as fifth-in-line, if Tottenham give the Argentine his chance.
The likelihood is that Spurs will bring in a new recruit to replace Alderweireld. Perhaps a player with more experience will instead be pursued.
Foyth has not yet proved himself in the Premier League, so laying it on the line for him next season would be a massive risk by Pochettino and Tottenham.
But there is certainly a chance that the £10 million youngster could take Alderweireld’s place next season.